Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stromal Cells as Cell-Based Therapeutics for Wound Healing
Chronic wounds are a source of substantial morbidity for patients and are a major financial burden for the healthcare system. There are no current therapies that reliably improve nonhealing wounds or reverse pathological scarring. Mesenchymal stromal cells (MSCs) are a promising source of novel cell-based therapies due to the ease of their harvest and their integral role in the native wound rep...
متن کاملTumor and Stem Cell Biology Mesenchymal Stromal Cell Mutations and Wound Healing Contribute to the Etiology of Desmoid Tumors
Desmoid tumors are nonmalignant neoplasms of mesenchymal origin that mainly contain fibroblast lineage cells. These tumors often occur in patients with familial adenomatous polyposis (FAP) coli who have germ line mutations in the APC gene. Given emerging data that has implicated multipotent mesencyhmal stromal cells (MSC) in the origin ofmesenchymal tumors, we hypothesized that desmoid tumorsma...
متن کاملthe role of mesenchymal stem cells in skin wound healing
mesenchymal stem cells (mscs) could differentiate into various types of tissues. these cells serve as a backup for the regeneration and repair of tissues or cells after injury. a skin wound is defined as an injury to the skin that needs to be restored. all types of cells in skin especially mesenchymal stem cells play important role in wound healing process. in particular, paracrine signaling of...
متن کاملMesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors.
Desmoid tumors are nonmalignant neoplasms of mesenchymal origin that mainly contain fibroblast lineage cells. These tumors often occur in patients with familial adenomatous polyposis (FAP) coli who have germ line mutations in the APC gene. Given emerging data that has implicated multipotent mesencyhmal stromal cells (MSC) in the origin of mesenchymal tumors, we hypothesized that desmoid tumors ...
متن کاملThe role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice
Mesenchymal stromal cells (MSCs) have shown to be a promising tool in cell therapies to treat different conditions. Several pre-clinical and clinical studies have proved that the transplantation of MSCs improves wound healing. Here, we compare the beneficial effects of mouse bone marrow-derived allogeneic MSCs (allo-mBM-MSCs) and their acelullar derivatives (allo-acd-mMSCs) on skin wound healin...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2020
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2020.03.017